Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate pathway (PPP), and pyrimidine biosynthesis. However, the molecular mechanism by which EGFR signaling regulates cancer cell...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Makinoshima, Hideki, Takita, Masahiro, Saruwatari, Koichi, Umemura, Shigeki, Obata, Yuuki, Ishii, Genichiro, Matsumoto, Shingo, Sugiyama, Eri, Ochiai, Atsushi, Abe, Ryo, Goto, Koichi, Esumi, Hiroyasu, Tsuchihara, Katsuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498084/
https://ncbi.nlm.nih.gov/pubmed/26023239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660498
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