Therapeutic Priority of the PI3K/AKT/mTOR Pathway in Small Cell Lung Cancers as Revealed by a Comprehensive Genomic Analysis

INTRODUCTION: The information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approach to stratify the targetable alterations. METHODS: We performed whole exon sequencing (n = 51) and copy...

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Detalhes bibliográficos
Main Authors: Umemura, Shigeki, Mimaki, Sachiyo, Makinoshima, Hideki, Tada, Satoshi, Ishii, Genichiro, Ohmatsu, Hironobu, Niho, Seiji, Yoh, Kiyotaka, Matsumoto, Shingo, Takahashi, Akiko, Morise, Masahiro, Nakamura, Yuka, Ochiai, Atsushi, Nagai, Kanji, Iwakawa, Reika, Kohno, Takashi, Yokota, Jun, Ohe, Yuichiro, Esumi, Hiroyasu, Tsuchihara, Katsuya, Goto, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154841/
https://ncbi.nlm.nih.gov/pubmed/25122428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000250
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