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TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule
The microtubule-associated protein, TPX2, regulates the activity of the mitotic kinesin, Eg5, but the mechanism of regulation is not established. Using total internal reflection fluorescence microscopy, we observed that Eg5, in extracts of mammalian cells expressing Eg5-EGFP, moved processively towa...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4498074/ https://ncbi.nlm.nih.gov/pubmed/26018074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612903 |
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