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Co-Silencing of PKM-2 and MDR-1 Sensitizes Multidrug Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer

Tumor multidrug resistance (MDR) is a serious clinical challenge that significantly limits the effectiveness of cytotoxic chemotherapy. As such, complementary therapeutic strategies are being explored to prevent relapse. The altered metabolic state of cancer cells, which perform aerobic glycolysis,...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cancer Ther
Prif Awduron: Talekar, Meghna, Ouyang, Qijun, Goldberg, Michael S., Amiji, Mansoor M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497852/
https://ncbi.nlm.nih.gov/pubmed/25964202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0100
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