MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer

Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MD...

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Vydáno v:Sci Rep
Hlavní autoři: Yang, Xiaoqian, lyer, Arun K., Singh, Amit, Choy, Edwin, Hornicek, Francis J., Amiji, Mansoor M., Duan, Zhenfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330541/
https://ncbi.nlm.nih.gov/pubmed/25687880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08509
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