Combination wt-p53 and MicroRNA-125b Transfection in a Genetically Engineered Lung Cancer Model Using Dual CD44/EGFR-targeting Nanoparticles

Mutations in KRAS and p53 signaling pathways contribute to loss of responsiveness to current therapies and a decreased survival in lung cancer. In this study, we have investigated the delivery and transfection of wild-type (wt-) p53 and microRNA-125b (miR-125b) expressing plasmid DNA, in SK-LU-1 hum...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Talekar, Meghna, Trivedi, Malav, Shah, Parin, Ouyang, Qijun, Oka, Adwait, Gandham, Srujan, Amiji, Mansoor M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886932/
https://ncbi.nlm.nih.gov/pubmed/26686386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.225
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