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Co-Silencing of PKM-2 and MDR-1 Sensitizes Multidrug Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer
Tumor multidrug resistance (MDR) is a serious clinical challenge that significantly limits the effectiveness of cytotoxic chemotherapy. As such, complementary therapeutic strategies are being explored to prevent relapse. The altered metabolic state of cancer cells, which perform aerobic glycolysis,...
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| Veröffentlicht in: | Mol Cancer Ther |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497852/ https://ncbi.nlm.nih.gov/pubmed/25964202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0100 |
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