GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

Age-related frailty may be due to decreased skeletal muscle regeneration. The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear. Recent studies showed an age-related decrease in GDF11 and that GDF11 treatment improves muscle regeneration, which were contrary to prior studies. We...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Metab
Auteurs principaux: Egerman, Marc A., Cadena, Samuel M., Gilbert, Jason A., Meyer, Angelika, Nelson, Hallie N., Swalley, Susanne E., Mallozzi, Carolyn, Jacobi, Carsten, Jennings, Lori L., Clay, Ieuan, Laurent, Gaëlle, Ma, Shenglin, Brachat, Sophie, Lach-Trifilieff, Estelle, Shavlakadze, Tea, Trendelenburg, Anne-Ulrike, Brack, Andrew S., Glass, David J.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497834/
https://ncbi.nlm.nih.gov/pubmed/26001423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.05.010
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