GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

Age-related frailty may be due to decreased skeletal muscle regeneration. The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear. Recent studies showed an age-related decrease in GDF11 and that GDF11 treatment improves muscle regeneration, which were contrary to prior studies. We...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Egerman, Marc A., Cadena, Samuel M., Gilbert, Jason A., Meyer, Angelika, Nelson, Hallie N., Swalley, Susanne E., Mallozzi, Carolyn, Jacobi, Carsten, Jennings, Lori L., Clay, Ieuan, Laurent, Gaëlle, Ma, Shenglin, Brachat, Sophie, Lach-Trifilieff, Estelle, Shavlakadze, Tea, Trendelenburg, Anne-Ulrike, Brack, Andrew S., Glass, David J.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497834/
https://ncbi.nlm.nih.gov/pubmed/26001423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.05.010
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