Protein phosphatase 2A inhibition with LB100 enhances radiation-induced mitotic catastrophe and tumor growth delay in glioblastoma

Protein Phosphatase 2A (PP2A) is a tumor suppressor whose function is lost in many cancers. An emerging, though counterintuitive, therapeutic approach is inhibition of PP2A to drive damaged cells through the cell cycle, sensitizing them to radiation therapy. We investigated the effects of PP2A inhib...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Gordon, Ira K., Lu, Jie, Graves, Christian A., Huntoon, Kristin, Frerich, Jason M., Hanson, Ryan H., Wang, Xiaoping, Hong, Christopher S., Ho, Winson, Feldman, Michael J., Ikejiri, Barbara, Bisht, Kheem, Chen, Xiaoyuan S., Tandle, Anita, Yang, Chunzhang, Arscott, W. Tristram, Ye, Donald, Heiss, John D., Lonser, Russell R., Camphausen, Kevin, Zhuang, Zhengping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497833/
https://ncbi.nlm.nih.gov/pubmed/25939762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0614
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