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Proteostasis modulators prolong missense VHL protein activity and halt tumor progression
While missense mutations of von Hippel-Lindau disease (VHL) gene are the most common germline mutation underlying this heritable cancer syndrome, the mechanism of tumorigenesis is unknown. We found a quantitative reduction of missense mutant VHL protein (pVHL) in VHL-associated tumors associated wit...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563731/ https://ncbi.nlm.nih.gov/pubmed/23318261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.12.007 |
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