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Proteostasis modulators prolong missense VHL protein activity and halt tumor progression

While missense mutations of von Hippel-Lindau disease (VHL) gene are the most common germline mutation underlying this heritable cancer syndrome, the mechanism of tumorigenesis is unknown. We found a quantitative reduction of missense mutant VHL protein (pVHL) in VHL-associated tumors associated wit...

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Main Authors: Yang, Chunzhang, Huntoon, Kristin, Ksendzovsky, Alexander, Zhuang, Zhengping, Lonser, Russell R.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563731/
https://ncbi.nlm.nih.gov/pubmed/23318261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.12.007
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