Inhibition of PLK1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitization

Glioblastoma multiforme (GBM) is the most common primary brain tumor in the USA with a median survival of approximately 14 months. Low survival rates are attributable to the aggressiveness of GBM and a lack of understanding of the molecular mechanisms underlying GBM. The disruption of signaling path...

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Main Authors: Tandle, Anita T., Kramp, Tamalee, Kil, Whoon J, Halthore, Aditya, Gehlhaus, Kristen, Shankavaram, Uma, Tofilon, Philip J., Caplen, Natasha J., Camphausen, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755049/
https://ncbi.nlm.nih.gov/pubmed/23790466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2013.05.013
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