Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell–autonomous growth or the host microenvironment or have off-target effec...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Xiang, Yan, Stine, Zachary E., Xia, Jinsong, Lu, Yunqi, O’Connor, Roddy S., Altman, Brian J., Hsieh, Annie L., Gouw, Arvin M., Thomas, Ajit G., Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S., Zhuo, Jingli, Ooi, London L., Lee, Caroline G.L., Mancuso, Anthony, McCallion, Andrew S., Le, Anne, Milone, Michael C., Rayport, Stephen, Felsher, Dean W., Dang, Chi V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497742/
https://ncbi.nlm.nih.gov/pubmed/25915584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75836
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