Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell–autonomous growth or the host microenvironment or have off-target effec...

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Pubblicato in:J Clin Invest
Autori principali: Xiang, Yan, Stine, Zachary E., Xia, Jinsong, Lu, Yunqi, O’Connor, Roddy S., Altman, Brian J., Hsieh, Annie L., Gouw, Arvin M., Thomas, Ajit G., Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S., Zhuo, Jingli, Ooi, London L., Lee, Caroline G.L., Mancuso, Anthony, McCallion, Andrew S., Le, Anne, Milone, Michael C., Rayport, Stephen, Felsher, Dean W., Dang, Chi V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497742/
https://ncbi.nlm.nih.gov/pubmed/25915584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75836
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