Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell–autonomous growth or the host microenvironment or have off-target effec...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xiang, Yan, Stine, Zachary E., Xia, Jinsong, Lu, Yunqi, O’Connor, Roddy S., Altman, Brian J., Hsieh, Annie L., Gouw, Arvin M., Thomas, Ajit G., Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S., Zhuo, Jingli, Ooi, London L., Lee, Caroline G.L., Mancuso, Anthony, McCallion, Andrew S., Le, Anne, Milone, Michael C., Rayport, Stephen, Felsher, Dean W., Dang, Chi V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497742/
https://ncbi.nlm.nih.gov/pubmed/25915584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75836
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