PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its downstream effector Akt kinase. Here we show that PS1, a protein involved in familial Alzheimer's disease (FAD), promotes cell survival by activating the PI3K/Akt cell survival signaling. This functi...

Full description

Saved in:
Bibliographic Details
Published in:EMBO J
Main Authors: Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
Subjects:
Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449766/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15192701/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600251
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items