PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its downstream effector Akt kinase. Here we show that PS1, a protein involved in familial Alzheimer's disease (FAD), promotes cell survival by activating the PI3K/Akt cell survival signaling. This functi...

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Autors principals: Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC449766/
https://ncbi.nlm.nih.gov/pubmed/15192701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600251
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