Trial of a 5-Day Dosing Regimen of Temozolomide in Patients with Relapsed Small Cell Lung Cancers with Assessment of Methylguanine-DNA Methyltransferase

OBJECTIVES: Small cell lung cancers (SCLCs) are characterized by aberrantly-methylated O(6)-methyl-guanine-DNA methyltransferase (MGMT). Epigenetic silencing of MGMT is associated with loss of MGMT activity and improved sensitivity to alkylating agents in glioblastomas. We have reported the activity...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Lung Cancer
मुख्य लेखकों: Zauderer, Marjorie G., Drilon, Alex, Kadota, Kyuichi, Huberman, Kety, Sima, Camelia S., Bergagnini, Isabella, Sumner, Dyana K., Travis, William D., Heguy, Adriana, Ginsberg, Michelle S., Holodny, Andrei I., Riely, Gregory J., Kris, Mark G., Krug, Lee M., Pietanza, M. Catherine
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2014
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497567/
https://ncbi.nlm.nih.gov/pubmed/25194640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2014.08.007
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