Hepatitis C virus mutation affects proteasomal epitope processing

The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an immunodominant HLA-A2–restricted CD8 cell epitope...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, Ruppert, Thomas, Rispeter, Kay, Henklein, Peter, Sijts, Alice, Hengel, Hartmut, Kloetzel, Peter-M., Rehermann, Barbara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2004
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449747/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254592/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20985
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