Hepatitis C virus mutation affects proteasomal epitope processing

The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an immunodominant HLA-A2–restricted CD8 cell epitope...

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Main Authors: Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, Ruppert, Thomas, Rispeter, Kay, Henklein, Peter, Sijts, Alice, Hengel, Hartmut, Kloetzel, Peter-M., Rehermann, Barbara
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2004
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC449747/
https://ncbi.nlm.nih.gov/pubmed/15254592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420985
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