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DksA and (p)ppGpp Have Unique and Overlapping Contributions to Haemophilus ducreyi Pathogenesis in Humans

The (p)ppGpp-mediated stringent response is important for bacterial survival in nutrient limiting conditions. For maximal effect, (p)ppGpp interacts with the cofactor DksA, which stabilizes (p)ppGpp's interaction with RNA polymerase. We previously demonstrated that (p)ppGpp was required for the...

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Publicado en:Infect Immun
Autores principales: Holley, Concerta L., Zhang, Xinjun, Fortney, Kate R., Ellinger, Sheila, Johnson, Paula, Baker, Beth, Liu, Yunlong, Janowicz, Diane M., Katz, Barry P., Munson, Robert S., Spinola, Stanley M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496623/
https://ncbi.nlm.nih.gov/pubmed/26056381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00692-15
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