A (p)ppGpp-Null Mutant of Haemophilus ducreyi Is Partially Attenuated in Humans Due to Multiple Conflicting Phenotypes

(p)ppGpp responds to nutrient limitation through a global change in gene regulation patterns to increase survival. The stringent response has been implicated in the virulence of several pathogenic bacterial species. Haemophilus ducreyi, the causative agent of chancroid, has homologs of both relA and...

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Detalhes bibliográficos
Main Authors: Holley, Concerta, Gangaiah, Dharanesh, Li, Wei, Fortney, Kate R., Janowicz, Diane M., Ellinger, Sheila, Zwickl, Beth, Katz, Barry P., Spinola, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136218/
https://ncbi.nlm.nih.gov/pubmed/24914217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01994-14
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