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A (p)ppGpp-Null Mutant of Haemophilus ducreyi Is Partially Attenuated in Humans Due to Multiple Conflicting Phenotypes

(p)ppGpp responds to nutrient limitation through a global change in gene regulation patterns to increase survival. The stringent response has been implicated in the virulence of several pathogenic bacterial species. Haemophilus ducreyi, the causative agent of chancroid, has homologs of both relA and...

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Autors principals: Holley, Concerta, Gangaiah, Dharanesh, Li, Wei, Fortney, Kate R., Janowicz, Diane M., Ellinger, Sheila, Zwickl, Beth, Katz, Barry P., Spinola, Stanley M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136218/
https://ncbi.nlm.nih.gov/pubmed/24914217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01994-14
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