PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach for T-ALL treatment, however at present no definitive evidence indicated whic...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Lonetti, Annalisa, Cappellini, Alessandra, Spartà, Antonino Maria, Chiarini, Francesca, Buontempo, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Orsini, Ester, McCubrey, James A., Martelli, Alberto Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496363/
https://ncbi.nlm.nih.gov/pubmed/25871383
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