Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia

Polo-like kinases (PLKs) and Aurora kinases (AKs) act as key cell cycle regulators in healthy human cells. In cancer, these protein kinases are often overexpressed and dysregulated, thus contributing to uncontrolled cell proliferation and growth. T-cell acute lymphoblastic leukemia (T-ALL) is a hete...

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Detalhes bibliográficos
Main Authors: Spartà, Antonino Maria, Bressanin, Daniela, Chiarini, Francesca, Lonetti, Annalisa, Cappellini, Alessandra, Evangelisti, Cecilia, Evangelisti, Camilla, Melchionda, Fraia, Pession, Andrea, Bertaina, Alice, Locatelli, Franco, McCubrey, James A, Martelli, Alberto M
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111679/
https://ncbi.nlm.nih.gov/pubmed/24874015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29267
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