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Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia

Polo-like kinases (PLKs) and Aurora kinases (AKs) act as key cell cycle regulators in healthy human cells. In cancer, these protein kinases are often overexpressed and dysregulated, thus contributing to uncontrolled cell proliferation and growth. T-cell acute lymphoblastic leukemia (T-ALL) is a hete...

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書誌詳細
主要な著者: Spartà, Antonino Maria, Bressanin, Daniela, Chiarini, Francesca, Lonetti, Annalisa, Cappellini, Alessandra, Evangelisti, Cecilia, Evangelisti, Camilla, Melchionda, Fraia, Pession, Andrea, Bertaina, Alice, Locatelli, Franco, McCubrey, James A, Martelli, Alberto M
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111679/
https://ncbi.nlm.nih.gov/pubmed/24874015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29267
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