Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe

Mitosis is choreographed by a number of protein kinases including polo-like kinases and Aurora kinases. As these kinases are frequently dysregulated in cancers, small-molecule inhibitors have been developed for targeted anticancer therapies. Given that PLK1 and Aurora kinases possess both unique fun...

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Опубликовано в: :Oncotarget
Главные авторы: Li, Jingjing, Hong, Myung Jin, Chow, Jeremy P.H., Man, Wing Yu, Mak, Joyce P.Y., Ma, Hoi Tang, Poon, Randy Y.C.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496220/
https://ncbi.nlm.nih.gov/pubmed/25871386
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