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Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis

The ATR–CHK1–WEE1 kinase cascade's functions in the DNA damage checkpoints are well established. Moreover, its roles in the unperturbed cell cycle are also increasingly being recognized. In this connection, a number of small-molecule inhibitors of ATR, CHK1, and WEE1 are being evaluated in clin...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Oncotarget
Main Authors: Mak, Joyce P.Y., Man, Wing Yu, Ma, Hoi Tang, Poon, Randy Y.C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279392/
https://ncbi.nlm.nih.gov/pubmed/25301733
תגים: הוספת תג
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