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Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint
Dovitinib (TKI258; formerly CHIR-258) is an orally bioavailable inhibitor of multiple receptor tyrosine kinases. Interestingly, Dovitinib triggered a G(2)/M arrest in cancer cell lines from diverse origins including HeLa, nasopharyngeal carcinoma, and hepatocellular carcinoma. Single-cell analysis r...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Publishing Ltd
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3916126/ https://ncbi.nlm.nih.gov/pubmed/24238094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12176 |
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