Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe

Mitosis is choreographed by a number of protein kinases including polo-like kinases and Aurora kinases. As these kinases are frequently dysregulated in cancers, small-molecule inhibitors have been developed for targeted anticancer therapies. Given that PLK1 and Aurora kinases possess both unique fun...

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Vydáno v:Oncotarget
Hlavní autoři: Li, Jingjing, Hong, Myung Jin, Chow, Jeremy P.H., Man, Wing Yu, Mak, Joyce P.Y., Ma, Hoi Tang, Poon, Randy Y.C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496220/
https://ncbi.nlm.nih.gov/pubmed/25871386
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