Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms

Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and metastatic cancer cells, particularly oral squamous cell carcinoma (OSCC) cells that cause most oral cancers. Here, we studied how a monoclonal...

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Publicado en:Oncotarget
Autores principales: Ochoa-Alvarez, Jhon A., Krishnan, Harini, Pastorino, John G., Nevel, Evan, Kephart, David, Lee, Joseph J., Retzbach, Edward P., Shen, Yongquan, Fatahzadeh, Mahnaz, Baredes, Soly, Kalyoussef, Evelyne, Honma, Masaru, Adelson, Martin E., Kaneko, Mika K., Kato, Yukinari, Young, Mary Ann, Deluca-Rapone, Lisa, Shienbaum, Alan J., Yin, Kingsley, Jensen, Lasse D., Goldberg, Gary S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496201/
https://ncbi.nlm.nih.gov/pubmed/25826087
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