Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration

Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer deaths. Extracellular receptors modified by α2,3-sialic acids that promote this motility can serve as ideal chemotherapeutic targets. For exam...

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Main Authors: Ochoa-Alvarez, Jhon Alberto, Krishnan, Harini, Shen, Yongquan, Acharya, Nimish K., Han, Min, McNulty, Dean E., Hasegawa, Hitoki, Hyodo, Toshinori, Senga, Takeshi, Geng, Jian-Guo, Kosciuk, Mary, Shin, Seung S., Goydos, James S., Temiakov, Dmitry, Nagele, Robert G., Goldberg, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402461/
https://ncbi.nlm.nih.gov/pubmed/22844530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041845
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