Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants

Genomic alterations targeting the Epidermal Growth Factor Receptor (EGFR) gene have been strongly associated with cancer pathogenesis. The clinical effectiveness of EGFR targeted therapies, including small molecules directed against the kinase domain such as gefitinib, erlotinib and afatinib, have b...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Park, Angela K.J., Francis, Joshua M., Park, Woong-Yang, Park, Joon-Oh, Cho, Jeonghee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496187/
https://ncbi.nlm.nih.gov/pubmed/25826094
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