Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab

BACKGROUND: Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human cancers. Enzymatic EGFR inhibitors are effective for lung adenocarcinomas with s...

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Main Authors: Cho, Jeonghee, Bass, Adam J, Lawrence, Michael S, Cibulskis, Kristian, Cho, Ahye, Lee, Shi-Nai, Yamauchi, Mai, Wagle, Nikhil, Pochanard, Panisa, Kim, Nayoung, Park, Angela KJ, Won, Jonghwa, Hur, Hyung-Suk, Greulich, Heidi, Ogino, Shuji, Sougnez, Carrie, Voet, Douglas, Tabernero, Josep, Jimenez, Jose, Baselga, Jose, Gabriel, Stacey B, Lander, Eric S, Getz, Gad, Eck, Michael J, Park, Woong-Yang, Meyerson, Matthew
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072491/
https://ncbi.nlm.nih.gov/pubmed/24894453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-141
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