A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging

Mutations of mitochondrial (mt)DNA cause a variety of human diseases and are implicated in premature aging syndromes. Here we investigated a single nucleotide exchange (leucine to methionine) at position nt4738 in the mitochondrial NADH dehydrogenase subunit 2 (Nd2) gene of the respiratory chain. Pr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Schauer, Marianne, Kottek, Tina, Schönherr, Madeleine, Bhattacharya, Animesh, Ibrahim, Saleh M, Hirose, Misa, Köhling, Rüdiger, Fuellen, Georg, Schmitz, Ulf, Kunz, Manfred
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Gerotarget (Focus on Aging): Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496166/
https://ncbi.nlm.nih.gov/pubmed/25839158
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