Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57(KIP2)

We show that two host-encoded primary RNAs (pri-miRs) and the corresponding microRNA (miR) clusters – widely reported to have cell transformation-associated activity – are regulated by EBNA3A and EBNA3C. Utilising a variety of EBV-transformed lymphoblastoid cell lines (LCLs) carrying knockout-, reve...

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Bibliografske podrobnosti
izdano v:PLoS Pathog
Main Authors: Bazot, Quentin, Paschos, Kostas, Skalska, Lenka, Kalchschmidt, Jens S., Parker, Gillian A., Allday, Martin J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496050/
https://ncbi.nlm.nih.gov/pubmed/26153983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005031
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