TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis

Mechanistic understanding of the preferential homing of circulating tumor cells to bone and their perturbation on bone metabolism within the tumor–bone microenvironment remains poorly understood. Alteration in both transforming growth factor β (TGFβ) signaling and sphingolipid metabolism results in...

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Vydáno v:Bonekey Rep
Hlavní autoři: Stayrook, Keith R, Mack, Justin K, Cerabona, Donna, Edwards, Daniel F, Bui, Hai H, Niewolna, Maria, Fournier, Pierrick GJ, Mohammad, Khalid S, Waning, David L, Guise, Theresa A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495778/
https://ncbi.nlm.nih.gov/pubmed/26157579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bonekey.2015.88
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