TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis

Mechanistic understanding of the preferential homing of circulating tumor cells to bone and their perturbation on bone metabolism within the tumor–bone microenvironment remains poorly understood. Alteration in both transforming growth factor β (TGFβ) signaling and sphingolipid metabolism results in...

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Publicado no:Bonekey Rep
Main Authors: Stayrook, Keith R, Mack, Justin K, Cerabona, Donna, Edwards, Daniel F, Bui, Hai H, Niewolna, Maria, Fournier, Pierrick GJ, Mohammad, Khalid S, Waning, David L, Guise, Theresa A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495778/
https://ncbi.nlm.nih.gov/pubmed/26157579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bonekey.2015.88
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