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A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are major downstream effectors of the Hippo pathway that influences tissue homeostasis, organ size, and cancer development. Aberrant hyperactivation of YAP/TAZ causes tissue overgrowth and tumorigenesis, wherea...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495398/ https://ncbi.nlm.nih.gov/pubmed/26109050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262816.115 |
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