A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are major downstream effectors of the Hippo pathway that influences tissue homeostasis, organ size, and cancer development. Aberrant hyperactivation of YAP/TAZ causes tissue overgrowth and tumorigenesis, wherea...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Moroishi, Toshiro, Park, Hyun Woo, Qin, Baodong, Chen, Qian, Meng, Zhipeng, Plouffe, Steven W., Taniguchi, Koji, Yu, Fa-Xing, Karin, Michael, Pan, Duojia, Guan, Kun-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495398/
https://ncbi.nlm.nih.gov/pubmed/26109050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262816.115
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