Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic inter...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Cuyàs, Elisabet, Fernández-Arroyo, Salvador, Corominas-Faja, Bruna, Rodríguez-Gallego, Esther, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, De Llorens, Rafael, Joven, Jorge, Menendez, Javier A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494938/
https://ncbi.nlm.nih.gov/pubmed/25980580
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