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First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation

ABSTRACT: A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C–H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selecti...

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Detalhes bibliográficos
Publicado no:Monatsh Chem
Main Authors: Schwarz, Maria C., Dastbaravardeh, Navid, Kirchner, Karl, Schnürch, Michael, Mihovilovic, Marko D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494768/
https://ncbi.nlm.nih.gov/pubmed/26166880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-013-0947-1
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