Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Lesinurad is a selective uric acid reabsorption inhibitor under investigation for the treatment of gout. Single and multiple ascending dose studies were conducted to evaluate pharmacokinetics, pharmacodynamics, and safety of lesinurad in healthy males. Lesinurad was administered as an oral solution...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Shen, Zancong, Rowlings, Colin, Kerr, Brad, Hingorani, Vijay, Manhard, Kimberly, Quart, Barry, Yeh, Li-Tain, Storgard, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494180/
https://ncbi.nlm.nih.gov/pubmed/26170627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S85193
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