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Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Lesinurad is a selective uric acid reabsorption inhibitor under investigation for the treatment of gout. Single and multiple ascending dose studies were conducted to evaluate pharmacokinetics, pharmacodynamics, and safety of lesinurad in healthy males. Lesinurad was administered as an oral solution...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Shen, Zancong, Rowlings, Colin, Kerr, Brad, Hingorani, Vijay, Manhard, Kimberly, Quart, Barry, Yeh, Li-Tain, Storgard, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494180/
https://ncbi.nlm.nih.gov/pubmed/26170627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S85193
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