The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, the building blocks for DNA synthesis, and are found in all but a few organisms. RNRs use radical chemistry to catalyze the reduction reaction. Despite RNR having evolved several mechanisms for genera...

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Veröffentlicht in:PLoS One
Hauptverfasser: Aurelius, Oskar, Johansson, Renzo, Bågenholm, Viktoria, Lundin, Daniel, Tholander, Fredrik, Balhuizen, Alexander, Beck, Tobias, Sahlin, Margareta, Sjöberg, Britt-Marie, Mulliez, Etienne, Logan, Derek T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493059/
https://ncbi.nlm.nih.gov/pubmed/26147435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128199
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