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Glypican Is a Modulator of Netrin-Mediated Axon Guidance

Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan,...

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Vydáno v:PLoS Biol
Hlavní autoři: Blanchette, Cassandra R., Perrat, Paola N., Thackeray, Andrea, Bénard, Claire Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493048/
https://ncbi.nlm.nih.gov/pubmed/26148345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002183
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