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Glypican Is a Modulator of Netrin-Mediated Axon Guidance

Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan,...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Blanchette, Cassandra R., Perrat, Paola N., Thackeray, Andrea, Bénard, Claire Y.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493048/
https://ncbi.nlm.nih.gov/pubmed/26148345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002183
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