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Glypican Is a Modulator of Netrin-Mediated Axon Guidance

Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan,...

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Pubblicato in:PLoS Biol
Autori principali: Blanchette, Cassandra R., Perrat, Paola N., Thackeray, Andrea, Bénard, Claire Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493048/
https://ncbi.nlm.nih.gov/pubmed/26148345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002183
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