Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast Cancer Cell Lines

The mammalian target of rapamycin (mTOR), a vital component of signaling pathways involving PI3K/AKT, is an attractive therapeutic target in breast cancer. Everolimus, an allosteric mTOR inhibitor that inhibits the mTOR functional complex mTORC1, is approved for treatment of estrogen receptor positi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Leung, Euphemia Y., Askarian-Amiri, Marjan, Finlay, Graeme J., Rewcastle, Gordon W., Baguley, Bruce C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492962/
https://ncbi.nlm.nih.gov/pubmed/26148118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131400
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