Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therap...

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Bibliografiska uppgifter
I publikationen:Pharmacol Res Perspect
Huvudupphovsmän: Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley & Sons, Ltd 2015
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://ncbi.nlm.nih.gov/pubmed/26171237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.158
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