Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therap...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pharmacol Res Perspect
Egile Nagusiak: Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Ltd 2015
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://ncbi.nlm.nih.gov/pubmed/26171237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.158
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