Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therap...

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Veröffentlicht in:Pharmacol Res Perspect
Hauptverfasser: Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://ncbi.nlm.nih.gov/pubmed/26171237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.158
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