Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

Ketamine produces rapid and sustained antidepressant actions in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here we determined if modulation of neuronal activity in the infralimbic prefrontal cortex (IL-PFC) underlies the antidepressant...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fuchikami, Manabu, Thomas, Alexandra, Liu, Rongjian, Wohleb, Eric S., Land, Benjamin B., DiLeone, Ralph J., Aghajanian, George K., Duman, Ronald S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491758/
https://ncbi.nlm.nih.gov/pubmed/26056286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414728112
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