Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses

A single sub-anesthetic dose of ketamine, a short-acting NMDA receptor blocker, induces a rapid and prolonged antidepressant effect in treatment-resistant major depression. In animal models, ketamine (24 h) reverses depression-like behaviors and associated deficits in excitatory postsynaptic current...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Liu, Rong-Jian, Ota, Kristie T, Dutheil, Sophie, Duman, Ronald S, Aghajanian, George K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613616/
https://ncbi.nlm.nih.gov/pubmed/25759300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.70
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