GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

A single dose of the short-acting NMDA antagonist ketamine produces rapid and prolonged antidepressant effects in treatment-resistant patients with major depressive disorder (MDD), which are thought to occur via restoration of synaptic connectivity. However, acute dissociative side effects and event...

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Hlavní autoři: Liu, Rong-Jian, Fuchikami, Manabu, Dwyer, Jason M, Lepack, Ashley E, Duman, Ronald S, Aghajanian, George K
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773678/
https://ncbi.nlm.nih.gov/pubmed/23680942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.128
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