Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

Transforming growth factor β-activated kinase 1 (TAK1) is critical for survival of many KRAS mutated colorectal cancer cells, and TAK1 inhibition with 5Z-7-oxozeaenol has been associated with oxidative stress leading to tumor cell killing. When SW 620 and HCT 116 human colon cancer cells were treate...

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Publicat a:Redox Biol
Autors principals: Hrabe, Jennifer E., O’Leary, Brianne R., Fath, Melissa A., Rodman, Samuel N., Button, Anna M., Domann, Frederick E., Spitz, Douglas R., Mezhir, James J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491644/
https://ncbi.nlm.nih.gov/pubmed/26114584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.06.004
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